Get the best piles and fistula treatment in Jaipur with advanced laser proctology techniques. Dr. Manish Rajput, a renowned specialist, provides painless, quick, and highly effective treatments for piles, fissures, and fistula. Using cutting-edge laser technology, the procedures ensure minimal discomfort, no stitches, and faster recovery, helping patients return to their daily lives with ease. Dr. Rajput is committed to offering personalized care and long-term solutions, ensuring lasting relief and improved quality of life. With his expertise and modern facilities, you can expect safe and reliable treatment for all proctological conditions.
DR MANISH-2.pdf laser proctology piles and fistuladeepikavedyan
6 slides•19 views
Get the best piles and fistula treatment in Jaipur with advanced laser proctology techniques. Dr. Manish Rajput, a renowned specialist, provides painless, quick, and highly effective treatments for piles, fissures, and fistula. Using cutting-edge laser technology, the procedures ensure minimal discomfort, no stitches, and faster recovery, helping patients return to their daily lives with ease. Dr. Rajput is committed to offering personalized care and long-term solutions, ensuring lasting relief and improved quality of life. With his expertise and modern facilities, you can expect safe and reliable treatment for all proctological conditions.
Best Varicose Veins Treatment in Jaipurdeepikavedyan
6 slides•11 views
Varicose veins are enlarged veins near the skin’s surface, often found in the legs due to increased pressure from standing and walking. For Best Varicose Veins Treatment in Jaipur, Dr. Manish Rajput provides advanced, personalized care using modern techniques to help you achieve healthier, smoother legs and a better quality of life.
Best Varicose Veins Treatment in Jaipurdeepikavedyan
6 slides•10 views
Varicose veins are enlarged veins near the skin’s surface, often found in the legs due to increased pressure from standing and walking. For Best Varicose Veins Treatment in Jaipur, Dr. Manish Rajput provides advanced, personalized care using modern techniques to help you achieve healthier, smoother legs and a better quality of life.
2024 Trend Updates: What Really Works In SEO & Content MarketingSearch Engine Journal
21 slides•634.1K views
The future of SEO is trending toward a more human-first and user-centric approach, powered by AI intelligence and collaboration. Are you ready?
Watch as we explore which SEO trends to prioritize to achieve sustainable growth and deliver reliable results. We’ll dive into best practices to adapt your strategy around industry-wide disruptions like SGE, how to navigate the top challenges SEO professionals are facing, and proven tactics for prioritizing quality and building trust.
You’ll hear:
- The top SEO trends to prioritize in 2024 to achieve long-term success.
- Predictions for SGE’s impact, and how to adapt.
- What E-E-A-T really means, and how to implement it holistically (hint: it’s never been more important).
With Zack Kadish and Alex Carchietta, we’ll show you which SEO trends to ignore and which to focus on, along with the solution to overcoming rapid, significant and disruptive Google algorithm updates.
If you’re looking to cut through the noise of constant SEO and content trends to drive success, you won’t want to miss this webinar.
Storytelling For The Web: Integrate Storytelling in your Design ProcessChiara Aliotta
39 slides•517.6K views
In this slides I explain how I have used storytelling techniques to elevate websites and brands and create memorable user experiences. You can discover practical tips as I showcase the elements of good storytelling and its applied to some examples of diverse brands/projects..
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...SocialHRCamp
28 slides•159.1K views
Speaker: Lydia Di Francesco
In this workshop, participants will delve into the realm of AI and its profound potential to revolutionize employee wellness initiatives. From stress management to fostering work-life harmony, AI offers a myriad of innovative tools and strategies that can significantly enhance the wellbeing of employees in any organization. Attendees will learn how to effectively leverage AI technologies to cultivate a healthier, happier, and more productive workforce. Whether it's utilizing AI-powered chatbots for mental health support, implementing data analytics to identify internal, systemic risk factors, or deploying personalized wellness apps, this workshop will equip participants with actionable insights and best practices to harness the power of AI for boosting employee wellness. Join us and discover how AI can be a strategic partner towards a culture of wellbeing and resilience in the workplace.
2024 State of Marketing Report – by HubspotMarius Sescu
43 slides•120.4K views
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
Huntington's disease is a rare, inherited, progressive brain disorder caused by a defect in a single gene (HTT) leading to the breakdown of nerve cells, resulting in uncontrolled movements, cognitive decline, and emotional problems.
Adulterants screening in Herbal products using Modern Analytical Techniques28SamruddhiKadam
21 slides•199 views
Basic introduction to adulteration in Herbal products, M Pharm Pharmaceutical Analysis Semester 2
Basic types of Adulterations in herbal products.
Modern hyphenated techniques used in determination of adulteration of herbal drugs which includes TLC, HPTLC, HPLC, LC-MS, LC-NMR, SFC, LC-IR,etc.
Various modern analytical techniques used in Quantification of Adulterants present in herbal product.
Examples of various drugs causing adulteration in Herbal products.
This presentation provides a comprehensive overview of the Drugs and Cosmetics Act, 1940, and its associated rules from 1945. It covers the objectives of the Act, its significance in regulating the import, manufacture, distribution, and sale of drugs and cosmetics in India. Key definitions such as drugs, cosmetics, misbranded, adulterated, and spurious products are explained in detail. Additionally, it highlights the legal definitions and important schedules to the Act, ensuring clarity on regulatory standards. Essential roles such as Drug Inspector and Government Analyst are also discussed. This presentation is useful for pharmacy students, regulatory professionals, and individuals interested in pharmaceutical law.
Medicinal and Toilet Preparations Act, 1955 – Excise Duty Regulations on Alco...Dr.Navaneethakrishnan S
22 slides•203 views
This presentation provides a comprehensive overview of the Medicinal and Toilet Preparations Act, 1955, which regulates the excise duty on medicinal and cosmetic products containing alcohol, opium, or narcotics in India. It covers key definitions, the distinction between bonded and non-bonded manufactories, licensing requirements, excise duty regulations, manufacturing guidelines, and penalties for violations. Special provisions related to Ayurvedic preparations, government hospital exemptions, and testing procedures are also highlighted. The presentation is valuable for pharmacy students, regulatory professionals, manufacturers, and excise officers involved in the pharmaceutical and cosmetic industries.
There is always more than one neurone involved in the transmission of a nerve impulse from its origin to its destination, whether it is sensory or motor.
There is no physical contact between two neurones.
Synapse: The point at which the nerve impulse passes from the presynaptic neurone to the postsynaptic neurone.
Presynaptic Neurons: The neurons that carries action potential to the synapse.
Postsynaptic Neurons: Neurons that carries action potential away from the synapse.
Synaptic knobs or terminal boutons: At its free end, the axon of the presynaptic neurone breaks up into minute branches that terminate in small swellings.
These are in close proximity to the dendrites and the cell body of the postsynaptic neurone.
The space between them is the synaptic cleft.
Synaptic knobs contain spherical membrane bound synaptic vesicles, which store a chemical (the neurotransmitter) that is released into the synaptic cleft.
Neurotransmitters are synthesised by nerve cell bodies, actively transported along the axons and stored in the synaptic vesicles.
They are released by exocytosis in response to the action potential in the presynaptic neurons and diffuse across the synaptic cleft.
They act on specific receptor sites on the postsynaptic membrane.
Their action is short lived, because immediately they have acted on the postsynaptic cell such as a muscle fibre, they are either inactivated by enzymes or taken back into the synaptic knob.
Some important drugs act by mimicking, neutralising (antagonising), or prolonging normal actions of neurotransmitters.
Neurotransmitters usually have an excitatory effect on postsynaptic receptors but they are sometimes inhibitory.
There are more than 50 neurotransmitters in the brain and spinal cord including noradrenaline (norepinephrine), adrenaline (epinephrine), dopamine, histamine, serotonin, gamma aminobutyric acid (GABA) and acetylcholine.
Other substances, such as Neuropeptides (enkephalins, endorphins and substance P) have specialised roles in, for example, transmission of pain signals.
Excitatory neurotransmitters: Acetylcholine, Norepinephrine, Dopamine (Initiate New Impulse)
Inhibitory neurotransmitters: GABA, Serotonin, Glycine (Reduces the chance of new impulse, Hyperpolarization).
Lipid Autocoids: A Comprehensive Overview
Introduction
Lipid autocoids, also known as eicosanoids and related lipid mediators, are bioactive molecules derived from polyunsaturated fatty acids (PUFAs). These molecules play crucial roles in inflammation, immunity, hemostasis, cardiovascular function, and various physiological and pathological processes. Unlike classical hormones, lipid autocoids act locally, exerting their effects at or near their site of synthesis.
This document provides an in-depth analysis of lipid autocoids, covering their biosynthesis, classification, physiological roles, and clinical significance.
Classification of Lipid Autocoids
Lipid autocoids are broadly classified into the following categories:
1. Eicosanoids (Derived from Arachidonic Acid)
Prostaglandins (PGs)
Thromboxanes (TXs)
Leukotrienes (LTs)
Lipoxins (LXs)
2. Specialized Pro-resolving Mediators (SPMs)
Resolvins
Protectins
Maresins
3. Endocannabinoids
Anandamide (AEA)
2-Arachidonoylglycerol (2-AG)
4. Platelet-Activating Factor (PAF)
5. Sphingolipid-Derived Mediators
Sphingosine-1-Phosphate (S1P)
Ceramides
Biosynthesis of Lipid Autocoids
Lipid autocoids are derived from membrane phospholipids through enzymatic pathways:
1. Phospholipase A2 (PLA2) Activation:
PLA2 catalyzes the release of arachidonic acid (AA) from membrane phospholipids.
2. Cyclooxygenase (COX) Pathway:
Converts AA into prostaglandins and thromboxanes.
COX-1: Constitutive enzyme (housekeeping functions).
COX-2: Inducible enzyme (inflammation and pain response).
3. Lipoxygenase (LOX) Pathway:
Converts AA into leukotrienes and lipoxins.
5-LOX: Leads to leukotrienes (inflammation, bronchoconstriction).
12-LOX & 15-LOX: Lead to lipoxins (anti-inflammatory action).
4. Cytochrome P450 (CYP) Pathway:
Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
1. Inflammation and Immune Response
Prostaglandins (e.g., PGE2) modulate fever and pain.
Leukotrienes mediate allergic responses and asthma.
Lipoxins and resolvins promote resolution of inflammation.
2. Cardiovascular System
Thromboxanes (TXA2) induce platelet aggregation and vasoconstriction.
Prostacyclin (PGI2) inhibits platelet aggregation and promotes vasodilation.
EETs regulate blood pressure and vascular homeostasis.
3. Pulmonary Function
Leukotrienes (LTC4, LTD4, LTE4) are potent bronchoconstrictors.
PGE2 has bronchodilatory effects.
4. Renal Function
Prostaglandins regulate glomerular filtration rate and sodium excretion.
EETs contribute to natriuresis.
5. Neurotransmission and Pain
Endocannabinoids modulate pain perception and neuroprotection.
Prostaglandins contribute to central pain sensitization.
6. Reproductive System
P
Chair, Nitin Jain, MD, discusses chronic lymphocytic leukemia in this CME/AAPA activity titled “Time-Limited Innovation for CLL Control: Changing the Treatment Story With Evidence and Emerging Consensus on 1L BTKi -BCL2i Combinations.” For the full presentation, downloadable Practice Aid, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/4gi5jVw. CME/AAPA credit will be available until April 3, 2026.
AUTO-IMMUNE DISEASES AND RHEUMATOID ARTHRITISCyb3rBioX
41 slides•165 views
This presentation is your one-stop guide to everything you need to know about autoimmune diseases—especially Rheumatoid Arthritis. Designed to be easily understandable for everyone, from curious beginners to biology students, it blends solid information with a dash of humour. Expect clear explanations, funny images, memes, and comics that make learning fun and engaging. Whether you're just starting out or need a refresher, this complete package brings insight and entertainment together to make biology anything but boring!
Partial Reprogramming (OSK) Research Summarymaximuspeto
55 slides•13 views
In this presentation, Bill Faloon summarizes some recent research advances using partial reprogramming (Yamanaka factors "OSK") to extend reproductive health and lifespan.
Personal Protective Equipment (PPE) refers to protective gear worn to prevent exposure to hazardous substances, objects, or environments. Types of PPE include head and neck protection (hard hats, safety helmets), eye and face protection (safety glasses, goggles), hearing protection (earplugs, earmuffs), respiratory protection (respirators, masks), hand and arm protection (gloves, sleeves), body protection (lab coats, coveralls), and foot and leg protection (safety shoes, boots). PPE is designed to prevent injuries and illnesses in various industries, including construction, manufacturing, and healthcare.
Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis)RheannaRandazzo
19 slides•313 views
Making meaning from hardship is a complex conversation. Many cancer survivors feel the delicate balance between making meaning and the internalized or external pressure that often follows a cancer diagnosis. Questions such as “What now?” are common when treatment ends. Well-meaning friends and family may subtly (or not so subtly) expect us to behave or view the world differently. If figuring out who you are now feels puzzling, join us on Wednesday, December 11th. Together, we will discuss how changes in your identity and perspective are a valid and essential part of this journey. Research has shown us how making meaning after hardship facilitates adjustment and well-being.
Post-exercise thermoregulation and associated factorsProf. Walid Kamal
14 slides•13 views
Post-exercise, especially in the heat, the body needs to restore its temperature balance. This process is complex, influenced by both thermal factors (like skin temperature) and nonthermal factors (like age, fitness, and blood pressure). These factors affect how quickly the body can lose heat and recover its core temperature. Understanding these influences is key to preventing heat strain and optimizing performance for athletes, workers, and military personnel.
Title: 📊 Pharmacoeconomics: History, Principles, Methods, and Applicationssakshiaggarwal979034
24 slides•346 views
📌 Description:
Pharmacoeconomics is a vital field that examines the economic impact of pharmaceutical products and healthcare services. This presentation provides a detailed overview of pharmacoeconomic principles, methodologies, and their significance in healthcare decision-making. It covers essential topics such as cost analysis, evaluation perspectives, and humanistic assessment methods.
💡 Key Topics Covered:
✔ History and Evolution of Pharmacoeconomics
✔ Goals and Objectives of Pharmacoeconomic Studies
✔ Cost Analysis & Consequences (Outcomes)
✔ Different Pharmacoeconomic Methodologies (Cost-Minimization, Cost-Effectiveness, Cost-Utility, Cost-Benefit)
✔ Perspectives in Economic Evaluations (Payer, Patient, Society)
✔ Role of Pharmacoeconomics in Drug Safety & Pharmacovigilance
✔ Humanistic Evaluation Methods (Quality of Life & Patient-Reported Outcomes)
✔ Importance of Pharmacoeconomics in Policy & Healthcare Decisions
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...Dr. Smita Kumbhar
36 slides•263 views
Good Automated Laboratory Practices (GALP) refers to a structured framework designed to ensure the reliability, accuracy, and integrity of data generated by automated laboratory systems. These practices encompass standard operating procedures (SOPs), regulatory compliance, software validation, and personnel training to maintain consistency in laboratory operations. GALP is essential for laboratories that rely on automation to process high volumes of data while ensuring regulatory adherence, particularly in pharmaceutical, biotechnology, and clinical research environments.
Principles of GALP
The fundamental principles of GALP include:
1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis.
2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines.
3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations.
4. System Validation: Regularly verifying automated instruments and software for functionality and compliance.
5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately.
6. Risk Management: Identifying and mitigating potential risks in automated workflows.
7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements.
GALP Requirements
To implement GALP, laboratories must adhere to certain requirements:
1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes.
2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements.
3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management.
4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines.
5. Personnel Competency: Conducting periodic training and assessments for laboratory staff.
6. Audit Readiness: Preparing for internal and external inspections by maintaining up-to-date documentation.
SOPs of GALP
Standard Operating Procedures (SOPs) form the backbone of GALP. These SOPs cover:
1. Instrument Calibration: Regular calibration and validation of automated instruments.
2. Data Entry and Management: Guidelines on recording, storing, and retrieving data in compliance with regulatory standards.
3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage.
4. Software Usage and Maintenance: Guidelines on software validation, updates, and troubleshooting.
5. Audit Trail Management: Recording and reviewing all modifications made to electronic data.
6. Corrective and Preventive Actions (CAPA): Addressing non-compliance and implementing necessary improvements.
Training Documentation
A key aspect of GALP is personnel training, which includes:
1. Training Plans
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
8 slides•51.8K views
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
Huntington's disease is a rare, inherited, progressive brain disorder caused by a defect in a single gene (HTT) leading to the breakdown of nerve cells, resulting in uncontrolled movements, cognitive decline, and emotional problems.
Adulterants screening in Herbal products using Modern Analytical Techniques28SamruddhiKadam
21 slides•199 views
Basic introduction to adulteration in Herbal products, M Pharm Pharmaceutical Analysis Semester 2
Basic types of Adulterations in herbal products.
Modern hyphenated techniques used in determination of adulteration of herbal drugs which includes TLC, HPTLC, HPLC, LC-MS, LC-NMR, SFC, LC-IR,etc.
Various modern analytical techniques used in Quantification of Adulterants present in herbal product.
Examples of various drugs causing adulteration in Herbal products.
This presentation provides a comprehensive overview of the Drugs and Cosmetics Act, 1940, and its associated rules from 1945. It covers the objectives of the Act, its significance in regulating the import, manufacture, distribution, and sale of drugs and cosmetics in India. Key definitions such as drugs, cosmetics, misbranded, adulterated, and spurious products are explained in detail. Additionally, it highlights the legal definitions and important schedules to the Act, ensuring clarity on regulatory standards. Essential roles such as Drug Inspector and Government Analyst are also discussed. This presentation is useful for pharmacy students, regulatory professionals, and individuals interested in pharmaceutical law.
Medicinal and Toilet Preparations Act, 1955 – Excise Duty Regulations on Alco...Dr.Navaneethakrishnan S
22 slides•203 views
This presentation provides a comprehensive overview of the Medicinal and Toilet Preparations Act, 1955, which regulates the excise duty on medicinal and cosmetic products containing alcohol, opium, or narcotics in India. It covers key definitions, the distinction between bonded and non-bonded manufactories, licensing requirements, excise duty regulations, manufacturing guidelines, and penalties for violations. Special provisions related to Ayurvedic preparations, government hospital exemptions, and testing procedures are also highlighted. The presentation is valuable for pharmacy students, regulatory professionals, manufacturers, and excise officers involved in the pharmaceutical and cosmetic industries.
There is always more than one neurone involved in the transmission of a nerve impulse from its origin to its destination, whether it is sensory or motor.
There is no physical contact between two neurones.
Synapse: The point at which the nerve impulse passes from the presynaptic neurone to the postsynaptic neurone.
Presynaptic Neurons: The neurons that carries action potential to the synapse.
Postsynaptic Neurons: Neurons that carries action potential away from the synapse.
Synaptic knobs or terminal boutons: At its free end, the axon of the presynaptic neurone breaks up into minute branches that terminate in small swellings.
These are in close proximity to the dendrites and the cell body of the postsynaptic neurone.
The space between them is the synaptic cleft.
Synaptic knobs contain spherical membrane bound synaptic vesicles, which store a chemical (the neurotransmitter) that is released into the synaptic cleft.
Neurotransmitters are synthesised by nerve cell bodies, actively transported along the axons and stored in the synaptic vesicles.
They are released by exocytosis in response to the action potential in the presynaptic neurons and diffuse across the synaptic cleft.
They act on specific receptor sites on the postsynaptic membrane.
Their action is short lived, because immediately they have acted on the postsynaptic cell such as a muscle fibre, they are either inactivated by enzymes or taken back into the synaptic knob.
Some important drugs act by mimicking, neutralising (antagonising), or prolonging normal actions of neurotransmitters.
Neurotransmitters usually have an excitatory effect on postsynaptic receptors but they are sometimes inhibitory.
There are more than 50 neurotransmitters in the brain and spinal cord including noradrenaline (norepinephrine), adrenaline (epinephrine), dopamine, histamine, serotonin, gamma aminobutyric acid (GABA) and acetylcholine.
Other substances, such as Neuropeptides (enkephalins, endorphins and substance P) have specialised roles in, for example, transmission of pain signals.
Excitatory neurotransmitters: Acetylcholine, Norepinephrine, Dopamine (Initiate New Impulse)
Inhibitory neurotransmitters: GABA, Serotonin, Glycine (Reduces the chance of new impulse, Hyperpolarization).
Lipid Autocoids: A Comprehensive Overview
Introduction
Lipid autocoids, also known as eicosanoids and related lipid mediators, are bioactive molecules derived from polyunsaturated fatty acids (PUFAs). These molecules play crucial roles in inflammation, immunity, hemostasis, cardiovascular function, and various physiological and pathological processes. Unlike classical hormones, lipid autocoids act locally, exerting their effects at or near their site of synthesis.
This document provides an in-depth analysis of lipid autocoids, covering their biosynthesis, classification, physiological roles, and clinical significance.
Classification of Lipid Autocoids
Lipid autocoids are broadly classified into the following categories:
1. Eicosanoids (Derived from Arachidonic Acid)
Prostaglandins (PGs)
Thromboxanes (TXs)
Leukotrienes (LTs)
Lipoxins (LXs)
2. Specialized Pro-resolving Mediators (SPMs)
Resolvins
Protectins
Maresins
3. Endocannabinoids
Anandamide (AEA)
2-Arachidonoylglycerol (2-AG)
4. Platelet-Activating Factor (PAF)
5. Sphingolipid-Derived Mediators
Sphingosine-1-Phosphate (S1P)
Ceramides
Biosynthesis of Lipid Autocoids
Lipid autocoids are derived from membrane phospholipids through enzymatic pathways:
1. Phospholipase A2 (PLA2) Activation:
PLA2 catalyzes the release of arachidonic acid (AA) from membrane phospholipids.
2. Cyclooxygenase (COX) Pathway:
Converts AA into prostaglandins and thromboxanes.
COX-1: Constitutive enzyme (housekeeping functions).
COX-2: Inducible enzyme (inflammation and pain response).
3. Lipoxygenase (LOX) Pathway:
Converts AA into leukotrienes and lipoxins.
5-LOX: Leads to leukotrienes (inflammation, bronchoconstriction).
12-LOX & 15-LOX: Lead to lipoxins (anti-inflammatory action).
4. Cytochrome P450 (CYP) Pathway:
Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
1. Inflammation and Immune Response
Prostaglandins (e.g., PGE2) modulate fever and pain.
Leukotrienes mediate allergic responses and asthma.
Lipoxins and resolvins promote resolution of inflammation.
2. Cardiovascular System
Thromboxanes (TXA2) induce platelet aggregation and vasoconstriction.
Prostacyclin (PGI2) inhibits platelet aggregation and promotes vasodilation.
EETs regulate blood pressure and vascular homeostasis.
3. Pulmonary Function
Leukotrienes (LTC4, LTD4, LTE4) are potent bronchoconstrictors.
PGE2 has bronchodilatory effects.
4. Renal Function
Prostaglandins regulate glomerular filtration rate and sodium excretion.
EETs contribute to natriuresis.
5. Neurotransmission and Pain
Endocannabinoids modulate pain perception and neuroprotection.
Prostaglandins contribute to central pain sensitization.
6. Reproductive System
P
Chair, Nitin Jain, MD, discusses chronic lymphocytic leukemia in this CME/AAPA activity titled “Time-Limited Innovation for CLL Control: Changing the Treatment Story With Evidence and Emerging Consensus on 1L BTKi -BCL2i Combinations.” For the full presentation, downloadable Practice Aid, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/4gi5jVw. CME/AAPA credit will be available until April 3, 2026.
AUTO-IMMUNE DISEASES AND RHEUMATOID ARTHRITISCyb3rBioX
41 slides•165 views
This presentation is your one-stop guide to everything you need to know about autoimmune diseases—especially Rheumatoid Arthritis. Designed to be easily understandable for everyone, from curious beginners to biology students, it blends solid information with a dash of humour. Expect clear explanations, funny images, memes, and comics that make learning fun and engaging. Whether you're just starting out or need a refresher, this complete package brings insight and entertainment together to make biology anything but boring!
Partial Reprogramming (OSK) Research Summarymaximuspeto
55 slides•13 views
In this presentation, Bill Faloon summarizes some recent research advances using partial reprogramming (Yamanaka factors "OSK") to extend reproductive health and lifespan.
Personal Protective Equipment (PPE) refers to protective gear worn to prevent exposure to hazardous substances, objects, or environments. Types of PPE include head and neck protection (hard hats, safety helmets), eye and face protection (safety glasses, goggles), hearing protection (earplugs, earmuffs), respiratory protection (respirators, masks), hand and arm protection (gloves, sleeves), body protection (lab coats, coveralls), and foot and leg protection (safety shoes, boots). PPE is designed to prevent injuries and illnesses in various industries, including construction, manufacturing, and healthcare.
Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis)RheannaRandazzo
19 slides•313 views
Making meaning from hardship is a complex conversation. Many cancer survivors feel the delicate balance between making meaning and the internalized or external pressure that often follows a cancer diagnosis. Questions such as “What now?” are common when treatment ends. Well-meaning friends and family may subtly (or not so subtly) expect us to behave or view the world differently. If figuring out who you are now feels puzzling, join us on Wednesday, December 11th. Together, we will discuss how changes in your identity and perspective are a valid and essential part of this journey. Research has shown us how making meaning after hardship facilitates adjustment and well-being.
Post-exercise thermoregulation and associated factorsProf. Walid Kamal
14 slides•13 views
Post-exercise, especially in the heat, the body needs to restore its temperature balance. This process is complex, influenced by both thermal factors (like skin temperature) and nonthermal factors (like age, fitness, and blood pressure). These factors affect how quickly the body can lose heat and recover its core temperature. Understanding these influences is key to preventing heat strain and optimizing performance for athletes, workers, and military personnel.
Title: 📊 Pharmacoeconomics: History, Principles, Methods, and Applicationssakshiaggarwal979034
24 slides•346 views
📌 Description:
Pharmacoeconomics is a vital field that examines the economic impact of pharmaceutical products and healthcare services. This presentation provides a detailed overview of pharmacoeconomic principles, methodologies, and their significance in healthcare decision-making. It covers essential topics such as cost analysis, evaluation perspectives, and humanistic assessment methods.
💡 Key Topics Covered:
✔ History and Evolution of Pharmacoeconomics
✔ Goals and Objectives of Pharmacoeconomic Studies
✔ Cost Analysis & Consequences (Outcomes)
✔ Different Pharmacoeconomic Methodologies (Cost-Minimization, Cost-Effectiveness, Cost-Utility, Cost-Benefit)
✔ Perspectives in Economic Evaluations (Payer, Patient, Society)
✔ Role of Pharmacoeconomics in Drug Safety & Pharmacovigilance
✔ Humanistic Evaluation Methods (Quality of Life & Patient-Reported Outcomes)
✔ Importance of Pharmacoeconomics in Policy & Healthcare Decisions
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...Dr. Smita Kumbhar
36 slides•263 views
Good Automated Laboratory Practices (GALP) refers to a structured framework designed to ensure the reliability, accuracy, and integrity of data generated by automated laboratory systems. These practices encompass standard operating procedures (SOPs), regulatory compliance, software validation, and personnel training to maintain consistency in laboratory operations. GALP is essential for laboratories that rely on automation to process high volumes of data while ensuring regulatory adherence, particularly in pharmaceutical, biotechnology, and clinical research environments.
Principles of GALP
The fundamental principles of GALP include:
1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis.
2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines.
3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations.
4. System Validation: Regularly verifying automated instruments and software for functionality and compliance.
5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately.
6. Risk Management: Identifying and mitigating potential risks in automated workflows.
7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements.
GALP Requirements
To implement GALP, laboratories must adhere to certain requirements:
1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes.
2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements.
3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management.
4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines.
5. Personnel Competency: Conducting periodic training and assessments for laboratory staff.
6. Audit Readiness: Preparing for internal and external inspections by maintaining up-to-date documentation.
SOPs of GALP
Standard Operating Procedures (SOPs) form the backbone of GALP. These SOPs cover:
1. Instrument Calibration: Regular calibration and validation of automated instruments.
2. Data Entry and Management: Guidelines on recording, storing, and retrieving data in compliance with regulatory standards.
3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage.
4. Software Usage and Maintenance: Guidelines on software validation, updates, and troubleshooting.
5. Audit Trail Management: Recording and reviewing all modifications made to electronic data.
6. Corrective and Preventive Actions (CAPA): Addressing non-compliance and implementing necessary improvements.
Training Documentation
A key aspect of GALP is personnel training, which includes:
1. Training Plans
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
